Isaac Ssewanyana

Repeated malaria exposure reprograms Vδ2+ γδT cell chromatin accessibility and immune function toward a reversible hyporesponsive state

Whole-genome characterization of Plasmodium falciparum population structure and drug resistance across Uganda and neighboring countries

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

PfPHAST: Plasmodium falciparum Public Health Amplicon Sequencing Tool, a Streamlined Panel for Malaria Genomic Surveillance

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes in P. falciparum malaria and are maintained by parasite exposure.

The paper characterizes malaria-specific Tfh and Tr1 cells in a longitudinal cohort, finding overlapping phenotypes and showing their decline after transmission interruption.

CXCR6⁺ CD127- Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection

The paper identifies CXCR6⁺ CD127⁻ Tr1 cells as key regulators in Plasmodium falciparum infection, showing they balance immunity and parasite persistence.

The N-terminal region of malaria vaccine candidate Plasmodium falciparum asparagine-rich merozoite antigen is immunodominant and targeted by polyreactive antibodies

This study investigates B cell and antibody responses to PfARMA, finding that IgM and IgG predominantly target the N-terminal IDR1 region, but these responses do not correlate with protection against malaria.

Maternal malaria and early-life infections shape humoral immunity to P. falciparum in infants

The paper examines how maternal malaria and early-life infections affect P. falciparum-specific antibody responses in infants, finding no protective association between maternal antibodies or early infections and clinical malaria.

Targeted Metagenomics Reveals Hidden Chickenpox Epidemic Amid Mpox Surveillance in Uganda

The paper identifies a concurrent chickenpox outbreak during an Mpox outbreak in Uganda by analyzing metagenomic data from Mpox-negative samples.

Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health

The paper develops MAD4HatTeR, an amplicon sequencing panel and analysis pipeline for detecting Plasmodium falciparum diversity, resistance markers, and gene duplications/deletions, showing high sensitivity and reproducibility across settings.

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens