Ole Isacson A

The paper measures GPNMB and glycosphingolipid levels in CSF and plasma from PD patients and controls, finding sex-based differences and associations with PD biomarkers.

This study shows APOE3 astrocytes rescue lipid-induced neurite damage in APOE4 neurons by enhancing lipid homeostasis through HDL-like particle production.

This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.