Targeting ZC3H12C improves T cell persistence and antitumor function in adoptive T cell therapy
Gayatri Kavishwar, Markus Perl, Christoph Heuser-Loy, Leonard Knoedler, Dhyani Shah, Fabio Mastrogiovanni, Konstantin Herfeld, Pedro Noronha, Manuela Kovács-Sautter, Maria Krieger, Stefan Loipfinger, Caio Raony Farina Silveira, Sascha Göttert, Roland Christian Schelker, Luisa-Marie Becker, , Christian Schmidl
This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.
bioRxiv · May 2, 2026 · PreprintImmunology