Stefan Loipfinger

Glutamine and GLS1 are key metabolic checkpoints that Limit T cell Infiltration and Function in HNSCC

This study identifies glutamine metabolism as a key mechanism limiting T cell infiltration and function in HNSCC, showing that targeting glutaminase-1 enhances immune response.

Targeting ZC3H12C improves T cell persistence and antitumor function in adoptive T cell therapy

This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.

PROTRIDER: Protein abundance outlier detection from mass spectrometry-based proteomics data with a conditional autoencoder

PROTRIDER detects protein expression outliers in proteomics data using conditional autoencoders, outperforming existing methods and revealing enrichments of pathogenic variants in outliers.

Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer

Integration of proteomics with genomics and transcriptomics increases the diagnostic rate of Mendelian disorders

Adding tandem mass tag proteomics to genome and transcriptome data resolved 22% of 121 unsolved suspected mitochondrial disease cases and surfaced two new disease genes.