Markus Perl

Targeting ZC3H12C improves T cell persistence and antitumor function in adoptive T cell therapy

This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.

A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.