Hendrik Poeck

Timed STING Inhibition Mitigates Gastrointestinal GvHD While Preserving Graft-versus-Leukemia Activity After Allo-HSCT

This study shows that timed STING inhibition reduces gastrointestinal GvHD without affecting GvL in mouse models, suggesting a potential therapeutic strategy for allo-HSCT.

Targeting ZC3H12C improves T cell persistence and antitumor function in adoptive T cell therapy

This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

A microbial metabolite protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.