Christian Schmidl

This study identifies glutamine metabolism as a key mechanism limiting T cell infiltration and function in HNSCC, showing that targeting glutaminase-1 enhances immune response.

This study shows that timed STING inhibition reduces gastrointestinal GvHD without affecting GvL in mouse models, suggesting a potential therapeutic strategy for allo-HSCT.

This study identifies SATB1 as a regulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells, showing its potential as a target for CAR T cell therapy.

This study identifies ZC3H12C as a target for improving T cell persistence and antitumor function in adoptive T cell therapy by disrupting its expression.

This study identifies desaminotyrosine (DAT) as a microbial metabolite that protects against graft-versus-host disease by promoting intestinal regeneration and modulating immune responses.

The paper maps DNA methylation in 580 animal species, revealing conserved and evolving patterns across vertebrates and invertebrates.

This paper introduces HT-ChIPmentation, a method that enables rapid ChIP-seq data generation from very low cell numbers by eliminating DNA purification and reducing reverse-crosslinking time.

This paper combines CRISPR genome editing with single-cell RNA sequencing to enable high-throughput screening with complex molecular read-outs.