Author

Barbora Svobodová

University Hospital Hradec KrálovéORCID 0000-0001-8099-089XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Alena RandákováiD· 1 shared Dominik NeliciD· 1 shared Eva DolejšíiD· 1 shared Eva MezeiováiD· 1 shared Ján JakubíkiD· 1 shared Jan KorábečnýiD· 1 shared Jana Bláhová· 1 shared John BoulosiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alena RandákováORCID

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1 paper

Recent·Most cited

Pharmacology & ToxicologyBiomedicine & PharmacotherapyPeer-reviewedOct 22, 2025

Balancing Rigidity and Flexibility: Optimised 4-(Hexyloxy)benzoate Antagonists with Enhanced Affinity and Tuneable Duration at Muscarinic Receptors

Eva Dolejší, Eva Mezeiová, Jana Bláhová…·Ján Jakubík

This study synthesizes and evaluates 4-(hexyloxy)benzoate derivatives to optimize muscarinic receptor antagonists, finding that rigid groups increase affinity but reduce duration, while flexible analogues balance potency and residence time.

DOI 10.1016/j.biopha.2025.118653

mechanistic / dynamical modeldrug response / drug discovery

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