Balancing Rigidity and Flexibility: Optimised 4-(Hexyloxy)benzoate Antagonists with Enhanced Affinity and Tuneable Duration at Muscarinic Receptors
Eva Dolejší, Eva Mezeiová, Jana Bláhová, Nikolai Chetverikov, Alena Randáková, Dominik Nelic, Lukáš Prchal, Barbora Svobodová, John Boulos, Jan Korábečný, Ján Jakubík
This study synthesizes and evaluates 4-(hexyloxy)benzoate derivatives to optimize muscarinic receptor antagonists, finding that rigid groups increase affinity but reduce duration, while flexible analogues balance potency and residence time.
Biomedicine & Pharmacotherapy · Oct 22, 2025Peer-reviewedPharmacology & Toxicology