Jan Korábečný

This study evaluates how impaired Mg2+ block at NMDA receptors affects the efficacy of K2060, memantine, and ketamine in protecting against audiogenic seizures.

This study synthesizes and evaluates 4-(hexyloxy)benzoate derivatives to optimize muscarinic receptor antagonists, finding that rigid groups increase affinity but reduce duration, while flexible analogues balance potency and residence time.

This paper develops a novel NMDA receptor open-channel blocker, K2060, showing improved efficacy and reversibility compared to existing drugs like memantine and dizocilpine.

This study develops novel NMDA receptor antagonists with neuroprotective effects and reduced psychomimetic side effects through structural modifications of MK-801.

This study evaluates dual-action tacrine derivatives as cholinesterase inhibitors and NMDA receptor antagonists for pro-cognitive effects in Alzheimer's disease models.

This study develops multi-target directed ligands (MTDLs) by modifying amiridine, a cholinesterase inhibitor, to enhance its therapeutic potential for Alzheimer's disease.

This study shows that structural changes in the ligand-binding domains of GluN1 and GluN2A subunits independently regulate early trafficking of NMDARs and that surface expression does not always correlate with agonist sensitivity.