Yadid M. Algavi

The paper analyzes the canine gut microbiome across 900 dogs to identify factors influencing microbiome composition and develops a metagenomics-based aging clock.

TAGINE optimizes microbiome feature sets using taxonomy-based splitting, reducing features while maintaining accuracy and speed.

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

The paper analyzes DNA methylation in dogs to identify age-related patterns, finding that LINE1 transposons show hypomethylation with age, varying by breed size and sex.

The paper develops an epigenetic clock for dogs using DNA methylation data to show that larger breeds age faster and have higher mortality risk.