Efrat Muller

MAAMOUL: Metabolic network-based discovery of microbiome-metabolome shifts in disease

MAAMOUL identifies disease-associated microbial metabolic modules by integrating metagenomic and metabolomic data through a metabolic network framework.

Mapping the canine microbiome: Insights from the Dog Aging Project

The paper analyzes the canine gut microbiome across 900 dogs to identify factors influencing microbiome composition and develops a metagenomics-based aging clock.

Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a new candidate biomarker of health

This study analyzes 11,115 global gut metagenomes to identify uncultured species linked to health and disease, finding CAG-170 as a potential biomarker of health.

DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project

The paper analyzes DNA methylation in dogs to identify age-related patterns, finding that LINE1 transposons show hypomethylation with age, varying by breed size and sex.

Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging.

The paper develops an epigenetic clock for dogs using DNA methylation data to show that larger breeds age faster and have higher mortality risk.

Multi-omic integration of microbiome data for identifying disease-associated modules

This paper introduces MintTea, a method for integrating multi-omic microbiome data to identify disease-associated modules, demonstrating its effectiveness across multiple datasets.

Data-driven dissection of the fever effect in autism spectrum disorder

The paper uses machine learning to analyze clinical data from the Simons Simplex Collection, finding associations between fever-induced behavioral improvements in ASD and maternal infection, GI dysfunction, and family history of autoimmune and neuropsychiatric disorders.