Noah Snyder‐Mackler

The paper compares left ventricular phenotypes across humans, chimpanzees, and macaques to identify structural and functional traits associated with higher stroke volume in humans.

This study shows that early-life wildfire smoke exposure in rhesus macaques leads to long-term immune and epigenetic changes, including altered cytokine responses and accelerated epigenetic aging.

This study examines how early life adversity affects adult behavior in free-ranging rhesus macaques, finding that ELA correlates with increased aggression, reduced grooming, and submissive behaviors.

This study shows that DNA methylation from fecal samples accurately reflects molecular aging in wild capuchin monkeys, revealing age-related epigenetic changes linked to cellular damage and inflammation.

The paper shows that age and early life adversity affect DNA methylation across tissues in macaques, with distinct but overlapping patterns.

This paper introduces an interpretable machine learning framework to infer dog breeds from genomic data, achieving high accuracy and identifying key genetic variants.

The paper analyzes the canine gut microbiome across 900 dogs to identify factors influencing microbiome composition and develops a metagenomics-based aging clock.

The paper quantifies variation in primate social structures across 11 species, identifying distinct patterns in kin and rank biases and male-centered subgrouping.

This study identifies blood biomarkers and genetic factors associated with aging in dogs using genomic and phenotypic data from 7,627 dogs.

The paper identifies shared plasma metabolomic biomarkers of mortality in dogs and humans, showing strong correlations between metabolite effects on all-cause mortality in both species.

This study profiles 5.3 million cells from 55 rhesus macaques across their lifespan to map age-related changes in brain cell types and identify molecular signatures linked to aging and Alzheimer's disease.

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

This study compares cardiac structure and function in free-ranging and captive rhesus macaques across age, finding that captive macaques show more pronounced age-related cardiac changes.

This study shows that early life adversity in rhesus macaques affects growth, reproductive timing, and lifetime reproductive success, with adversity intensifying trade-offs between growth and reproduction.

The paper optimizes a reduced representation DNA methylation sequencing protocol for cost-effective, population-scale studies across species.

The paper estimates realized relatedness in free-ranging macaques using IBD analysis from low coverage whole genome data, revealing genetic variation within kin classes and cryptic relatives.

The paper examines how reduced social connectedness in older primates can mitigate infection risks from a hypothetical pathogen, showing age-related changes in social behavior affect disease dynamics.

The paper analyzes DNA methylation in dogs to identify age-related patterns, finding that LINE1 transposons show hypomethylation with age, varying by breed size and sex.

The paper develops an epigenetic clock for dogs using DNA methylation data to show that larger breeds age faster and have higher mortality risk.

The paper analyzes sex-biased gene expression in rhesus macaque brains to understand its evolutionary and biomedical implications, finding similarities with human patterns and associations with neurodevelopmental disorders.

This study examines sex differences in immune function and disease risk across populations, finding no consistent support for the evolutionary mismatch hypothesis.

This study shows Mediterranean diets reduce neuroinflammation and protect brain structure and behavior in nonhuman primates by altering gene expression in the temporal cortex.

The paper creates a single-cell multi-omic atlas of the rhesus macaque brain, identifying cell-type-specific regulatory elements and providing insights into brain evolution and disease.

This study examines age-related changes in ocular features of rhesus macaques, finding associations between age and corneal thickness, axial length, refractive error, cataracts, and retinal drusen.

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

This study identifies genomic and karyotypic changes in geladas that may contribute to high-altitude adaptation and speciation.

This study examines how Western and Mediterranean diets affect monocyte gene expression and social behavior in macaques, finding proinflammatory gene changes and behavioral differences.

This study shows seasonal changes in the gut microbiome of wild geladas correlate with diet and environmental factors like rainfall and temperature.

This paper reviews rhesus macaques as a model for human ageing, showing shared gene regulatory signatures in immune ageing between macaques and humans.

This study shows that social status affects gene expression in immune cells of rhesus macaques, with effects modulated by pathogen exposure, type, and social history.