Blaise L. Mariner

Mapping the canine microbiome: Insights from the Dog Aging Project

The paper analyzes the canine gut microbiome across 900 dogs to identify factors influencing microbiome composition and develops a metagenomics-based aging clock.

Protein catabolites as blood-based biomarkers of aging physiology: Findings from the Dog Aging Project

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

Diverse Patterns of Allele-Specific Expression in Healthy Human Tissues

The paper quantifies interindividual variation in allele-specific expression across healthy human tissues using GTEx data, revealing gene-specific patterns and tissue-specific biases.

DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project

The paper analyzes DNA methylation in dogs to identify age-related patterns, finding that LINE1 transposons show hypomethylation with age, varying by breed size and sex.

Aging at scale: Younger dogs and larger breeds from the Dog Aging Project show accelerated epigenetic aging.

The paper develops an epigenetic clock for dogs using DNA methylation data to show that larger breeds age faster and have higher mortality risk.