Triple labeling resolves a GPCR intermediate state by 3-color single molecule FRET
Léo Bonhomme, Ecenaz Bilgen, Caroline Clerté, Jean‐Philippe Pin, Philippe Rondard, Emmanuel Margeat, Don C. Lamb, Robert B. Quast
This paper introduces a triple-labeling strategy for single molecule FRET to study conformational changes in GPCRs, revealing a previously unknown intermediate state.
Journal of the American Chemical Society · May 15, 2025Peer-reviewedBiophysics