Jean‐Philippe Pin

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

This study shows that chronic activation of mGlu2 receptors with a nanobody accelerates amyloid formation and worsens memory deficits in Alzheimer's disease models.

This study identifies non-canonical internalization mechanisms for mGlu receptors, showing some require neither GRKs nor beta-arrestins for agonist-induced internalization.

This paper introduces a triple-labeling strategy for single molecule FRET to study conformational changes in GPCRs, revealing a previously unknown intermediate state.

This study shows that APP17, a peptide derived from APP, does not regulate GABAB receptor activity in heterologous cells or neurons, suggesting sAPP acts through other receptors.

This study shows that EGF-induced dimer formation activates EGFR, and that TK inhibitors affect EGFR internalization based on dimer conformation.

This study shows that chronic sodium bromide treatment reduces autistic-like behaviors in three mouse models of autism, with synergistic effects when combined with an mGlu4 receptor modulator.