Author

Pedro Paranhos Tanaka

Universidade de São PauloORCID 0000-0001-8169-6975Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Geraldo Aleixo Silva PassosiD· 3 shared Max Jordan DuarteiD· 3 shared Amanda Freire AssisiD· 2 shared Mayara Cristina Vieira-Machado· 2 shared Romário S. MascarenhasiD· 2 shared Adriana Arruda MatosiD· 1 shared Alina O. Oliveira· 1 shared Ana C Monteleone-CassianoiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMolecular Biology

Geraldo Aleixo Silva PassosORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2026

Differential Cytotoxicity of PVP-Copper Nanoparticles in Breast Cancer Cell Lines: Insights from Basal Transcriptomic Profiles

Anelise Goncalves Silva, Izaque Junior Oliveira Silva, Pedro Paranhos Tanaka…·Cyro von Zuben de Valega Negrão

The paper evaluates the differential cytotoxicity of CuNP-PVP in breast cancer cell lines and identifies transcriptional programs associated with subtype-specific responses.

DOI 10.64898/2026.09.21.753010

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintOct 13, 2023

The ribonucleoprotein-mediated CRISPR-Cas9 system induces recurrent Aire gene mutations in contrast to the nickase expression vector in murine in vitro or in vivo models

Pedro Paranhos Tanaka, Cíntia Júnia Monteiro, Max Jordan Duarte…·Geraldo Aleixo Silva Passos

The paper compares CRISPR-Cas9 RNP and nickase systems for inducing Aire gene mutations in murine mTECs, finding recurrent mutations with RNP but not nickase.

2 citations

mouseCRISPR screen

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Molecular BiologyBMC GenomicsPeer-reviewedMay 28, 2022

miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

Pedro Paranhos Tanaka, Ernna Hérida Domingues de Oliveira, Mayara Cristina Vieira-Machado…·Geraldo Aleixo Silva Passos

The paper identifies miR-155 as a posttranscriptional regulator of Aire and TRA genes in mTECs, affecting chemotaxis.

6 citations

mousebulk RNA-seq

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Molecular BiologyMolecular ImmunologyPeer-reviewedOct 25, 2021

Autoimmune regulator act in synergism with thymocyte adhesion in the control of lncRNAs in medullary thymic epithelial cells

Max Jordan Duarte, Romário S. Mascarenhas, Amanda Freire Assis…·Geraldo Aleixo Silva Passos

The paper investigates the role of Aire in regulating lncRNA transcription in mTECs and identifies synergistic interactions with thymocyte adhesion.

8 citations

mousebulk RNA-seq

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