Nurdan Kuru

PHACTn predicts nucleotide variant tolerability across the genome without training, outperforming existing tools on non-coding variants from ClinVar and OMIM.

PHACE identifies co-evolving amino acid positions by incorporating phylogenetic dependencies, outperforming existing methods in accuracy.

PHACTboost improves missense variant pathogenicity prediction by integrating phylogenetic trees, multiple sequence alignments, and ancestral reconstruction, outperforming existing tools including AlphaMissense and CPT-1.