BioinformaticsbioRxivPreprint
PHACTboost: A Phylogeny-aware Boosting Algorithm to Compute the Pathogenicity of Missense Mutations
Onur Dereli, Nurdan Kuru, Emrah Akkoyun…·Ogün Adebalı
PHACTboost improves missense variant pathogenicity prediction by integrating phylogenetic trees, multiple sequence alignments, and ancestral reconstruction, outperforming existing tools including AlphaMissense and CPT-1.