Author

Onur Dereli

Sabancı ÜniversitesiORCID 0000-0002-2759-2793Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ogün AdebalıiD· 2 shared Aylin BırcaniD· 1 shared Berkay SelçukiD· 1 shared Emrah AkkoyuniD· 1 shared Nurdan KuruiD· 1 shared Öznur TaştaniD· 1 shared Tuana Aksu· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 13 mutual co-author links

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2 shared papersBioinformatics

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJan 30, 2024

PHACTboost: A Phylogeny-aware Boosting Algorithm to Compute the Pathogenicity of Missense Mutations

Onur Dereli, Nurdan Kuru, Emrah Akkoyun…·Ogün Adebalı

PHACTboost improves missense variant pathogenicity prediction by integrating phylogenetic trees, multiple sequence alignments, and ancestral reconstruction, outperforming existing tools including AlphaMissense and CPT-1.

2 citations

machine learning (classical)variant effect prediction

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GeneticsScientific ReportsPeer-reviewedDec 7, 2023

Downregulated NPAS4 in multiple brain regions is associated with Major Depressive Disorder

Berkay Selçuk, Tuana Aksu, Onur Dereli, Ogün Adebalı

This study identifies NPAS4 downregulation in multiple brain regions and links it to glutamatergic signaling disruption in Major Depressive Disorder.

10 citations

humanbulk RNA-seq

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