Author

Darren R. Hargrave

Great Ormond Street HospitalORCID 0000-0001-8219-9807Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Thomas S. JacquesiD· 2 shared Adrienne Margaret FlanaganiD· 1 shared Andrew R. J. LawsoniD· 1 shared Angel Montero CarcabosoiD· 1 shared Anna Tollit· 1 shared Ashley VardoniD· 1 shared Chris JonesiD· 1 shared Daniel Gharai· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Thomas S. JacquesORCID

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2 papers

Recent·Most cited

Cancer BiologyNature GeneticsPeer-reviewedFeb 25, 2025

Cancer-independent, second somatic NF1 mutation of normal tissues in neurofibromatosis type 1

Thomas R. W. Oliver, Andrew R. J. Lawson, Henry Lee-Six…·Sam Behjati

The paper identifies second somatic NF1 mutations in normal tissues of neurofibromatosis type 1 patients through whole genome and exome sequencing, showing positive selection of truncating mutations in these tissues.

14 citationstop 2%

humanwhole-exome sequencing

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Cancer BiologybioRxivPreprintDec 20, 2024

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon, Scott Haston, Romain Guiho…·Juan Pedro Martı́nez-Barberá

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

DOI 10.1101/2024.12.20.629607

humanbulk RNA-seq

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