Author

Daniel Gharai

University College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jesús GiliD· 2 shared Romain GuihoiD· 2 shared Scott HastoniD· 2 shared Akang Leonard Bassey· 1 shared Angel Montero CarcabosoiD· 1 shared Ashley Vardon· 1 shared Ashley VardoniD· 1 shared Chris JonesiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Jesús GilORCID

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2 papers

Recent·Most cited

Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

Romain Guiho, Hiba Hamdi, Grace Cooksley, Timoty H. Chang, Le Cao, Romain Sigaud, Sophie Bliss, Ashley Vardon, Scott Haston, Florian Selt, Akang Leonard Bassey, Daniela Kocher, Ria Kedia, Daniel Gharai, Jesús Gil, , Juan Pedro Martinez Barbera

This study shows that standard therapies for paediatric BRAF-V600E glioma induce senescence, which can be targeted by BCL-xL inhibitors to prevent tumour regrowth.

Neuro-Oncology · Oct 28, 2026Peer-reviewedCancer Biology

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

Ashley Vardon, Scott Haston, Romain Guiho, Diana Carvahlo, Rebecca Carter, Jessica K.R. Boult, Daniel Gharai, Diwakar Santhakumar, Ielyaas Cloete, James Gray, John Richard Apps, Olumide Kayode Ogunbiyi, Daohong Zhou, Guangrong Zheng, Ramón Martínez‐Máñez, , Juan Pedro Martı́nez-Barberá

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

bioRxiv · Dec 20, 2024 · PreprintCancer Biology