Romain Guiho

Standard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition

This study shows that standard therapies for paediatric BRAF-V600E glioma induce senescence, which can be targeted by BCL-xL inhibitors to prevent tumour regrowth.

Molecular and spatial profiling identifies immune endotypes for the stratification of OA patients

The paper identifies immune endotypes in OA synovial tissue using integrated molecular and spatial profiling to guide precision medicine.

Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs

This paper compares transcriptomic and functional differences between healthy and degenerated ovine intervertebral disc cells, finding age-related inflammatory and senescence signatures and shared transcriptional modules with human degenerated discs.

Multimodal analysis of osteoarthritic chondrocytes reveals mitochondrial alterations and patient-specific OxPhos response to bezafibrate

This study identifies mitochondrial alterations in osteoarthritic chondrocytes and shows that bezafibrate improves OxPhos function in a subset of patients.

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.