Developmental BiologybioRxivPreprint
Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids
Jinqiu Zhang, Jolene Ooi, Kagistia Hana Utami…·Mahmoud A. Pouladi
This study shows that expanded CAG repeats in HTT disrupt neural progenitor expansion and differentiation in human cerebral organoids, suggesting abnormal neurodevelopment in Huntington disease.
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