Author

Jolene Ooi

Agency for Science, Technology and Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

Mahmoud A. PouladiiD· 2 shared Bernard NgiD· 1 shared Chit Fang CheokiD· 1 shared Colin J. RossiD· 1 shared Dong Shin Park· 1 shared Enrico G. PetrettoiD· 1 shared Florent GinhouxiD· 1 shared Galen E.B. WrightiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Mahmoud A. PouladiORCID

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2 papers

Recent·Most cited

Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease

Galen E.B. Wright, Nicholas S. Caron, Bernard Ng, Lorenzo L. Casal, William Casazza, Xiaohong Xu, Jolene Ooi, Mahmoud A. Pouladi, Sara Mostafavi, Colin J. Ross, Michael R. Hayden

The paper identifies novel modifier genes for Huntington disease by combining population-scale gene expression data with patient genomic data.

Human Molecular Genetics · Aug 12, 2020Peer-reviewedGenomics

Expanded huntingtin CAG repeats disrupt the balance between neural progenitor expansion and differentiation in human cerebral organoids

Jinqiu Zhang, Jolene Ooi, Kagistia Hana Utami, Sarah R. Langley, Obed Akwasi Aning, Dong Shin Park, Magdalena Renner, Shiming Ma, Chit Fang Cheok, Juergen A. Knoblich, Florent Ginhoux, Enrico G. Petretto, Mahmoud A. Pouladi

This study shows that expanded CAG repeats in HTT disrupt neural progenitor expansion and differentiation in human cerebral organoids, suggesting abnormal neurodevelopment in Huntington disease.

bioRxiv · Nov 26, 2019 · PreprintDevelopmental Biology