Cancer BiologybioRxivPreprint
Exploring the mechanisms governing the initiation of plexiform neurofibromas using Prss56Cre,Nf1-KO mouse model at a single-cell resolution
Myriam Mansour, Audrey Onfroy, Fanny Coulpier…·Piotr Topilko
This study uses a Nf1-KO mouse model to investigate the initiation of plexiform neurofibromas, finding that skin trauma accelerates tumor development and that Nf1 heterozygosity contributes to mutant Schwann cell expansion.
DOI 10.1101/2025.07.04.662123