Piotr Topilko

This study uses single-cell RNA sequencing to identify distinct HF stem cell differentiation trajectories in HS patients, linking them to three clinical endotypes defined by inflammation, keratinization, and mixed features.

This study uses a Nf1-KO mouse model to investigate the initiation of plexiform neurofibromas, finding that skin trauma accelerates tumor development and that Nf1 heterozygosity contributes to mutant Schwann cell expansion.

This study shows that motor nerves guide the development of sympathetic ganglia by directing the migration and differentiation of neural crest-derived sympathoblasts.

The paper investigates the role of Netrin-1 and myelinating Schwann cells in regulating vascularization of the developing mouse sciatic nerve, showing Netrin-1 promotes vascular invasion during embryogenesis while Schwann cells reduce it postnatally.

This study shows that Schwann cells migrate along blood vessels in the demyelinated CNS via Eph/ephrin signaling, avoiding myelin and interacting with ECM components.