Fanny Coulpier

A systematic benchmark of bioinformatics methods for single-cell and spatial RNA-seq Nanopore long-read data

This study benchmarks bioinformatics methods for single-cell and spatial RNA-seq Nanopore long-read data, evaluating their accuracy, robustness, and scalability across different protocols and sequencing conditions.

A low CDKN1c/p57kip2 expression in spinal progenitors drives the transition from proliferative to neurogenic modes of division

The paper identifies CDKN1c/p57kip2 as a regulator of the transition from symmetric proliferative to asymmetric neurogenic divisions in spinal progenitors using single-cell RNA-seq data from chick embryos.

Hair follicle stem cell fate supports distinct clinical endotypes in Hidradenitis Suppurativa

This study uses single-cell RNA sequencing to identify distinct HF stem cell differentiation trajectories in HS patients, linking them to three clinical endotypes defined by inflammation, keratinization, and mixed features.

Exploring the mechanisms governing the initiation of plexiform neurofibromas using Prss56Cre,Nf1-KO mouse model at a single-cell resolution

This study uses a Nf1-KO mouse model to investigate the initiation of plexiform neurofibromas, finding that skin trauma accelerates tumor development and that Nf1 heterozygosity contributes to mutant Schwann cell expansion.

Motor nerves direct the development of the sympathetic nervous system

This study shows that motor nerves guide the development of sympathetic ganglia by directing the migration and differentiation of neural crest-derived sympathoblasts.

The pelvic organs receive no parasympathetic innervation

The paper uses single-cell RNA sequencing to show that the mouse pelvic ganglion contains neurons distinct from both sympathetic and parasympathetic types, and that pelvic organs are innervated by a divergent sympathetic pathway, not parasympathetic or typical sympathetic neurons.

Myelinating Schwann cells and Netrin-1 control intra-nervous vascularization of the developing mouse sciatic nerve

The paper investigates the role of Netrin-1 and myelinating Schwann cells in regulating vascularization of the developing mouse sciatic nerve, showing Netrin-1 promotes vascular invasion during embryogenesis while Schwann cells reduce it postnatally.

Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus

The paper identifies Clp1-mediated 3’UTR shortening as a post-transcriptional mechanism enhancing transcript stability of Aire-sensitive genes in thymic medullary epithelial cells.

Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling

This study shows that Schwann cells migrate along blood vessels in the demyelinated CNS via Eph/ephrin signaling, avoiding myelin and interacting with ECM components.

Active intermixing of indirect and direct neurons builds the striatal mosaic

The paper shows that indirect and direct striatal neurons intermix through active migration, with Ebf1 mutation disrupting this process and affecting striatal architecture.

Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice

This study shows that Egr1 deficiency promotes browning of inguinal white adipose tissue in mice by enhancing Ucp1 expression and reducing extracellular matrix genes.