Developmental BiologyDevelopmentPeer-reviewed
Huntingtin CAG expansion impairs germ layer patterning in synthetic human gastruloids through polarity defects.
Szilvia Galgoczi, Albert Ruzo, Christian Markopoulos…·Ali H. Brivanlou
This study shows that HTT-CAG expansion in human gastruloids causes ectodermal compartment reduction and altered TGFβ signaling due to polarity defects, indicating early developmental HD effects.
23 citations