Jakob Johannes Metzger

This study shows that spreading tau coordinates lipid homeostasis by promoting neuronal lipid efflux and enhancing resilience to lipid toxicity.

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

This study shows that HTT-CAG expansion in human gastruloids causes ectodermal compartment reduction and altered TGFβ signaling due to polarity defects, indicating early developmental HD effects.

The paper shows that WNT signaling memory enables ACTIVIN to act as a morphogen in human gastruloids by allowing graded responses to ACTIVIN without altering SMAD2 dynamics.

The paper generates a 3D human epiblast model to study axial symmetry breaking, showing BMP4 induces symmetry breaking through WNT3 and DKK1.

The paper develops a mouse pluripotent stem cell micropattern system to study regionalized fate specification and patterning, revealing how signals direct distinct identities and spatial organization.