Mandy Ng

This study shows that hypoxia induces left-looping heart development in surface fish, mimicking cavefish traits, and reveals a mechanistic link between hypoxia and evolutionary changes in heart asymmetry.

The paper shows that enhanced Sonic Hedgehog signaling in cavefish modifies left-right organizer function, leading to reversed heart asymmetry.

This study identifies a mutation in the cbsa gene as a contributor to eye loss in cavefish by disrupting optic vasculature and causing hypoxia.

This study examines evolutionary changes in left-right visceral asymmetry in Astyanax cavefish, identifying maternal genetic effects and regulatory changes in the lft2 gene.

The paper investigates the roles of the retinal pigment epithelium (RPE) and lens in cavefish eye degeneration by generating an albino-eyed strain and analyzing its developmental traits.