Brant M. Weinstein

This study identifies Shoc2 as a critical regulator of lymphangiogenesis by suppressing mTORC1-mediated IFN responses, leading to lymphatic vasculature loss and cellular senescence.

This study identifies and characterizes specialized endothelial cells in zebrafish gills that resemble mammalian lung aerocytes, using single-cell RNA sequencing and advanced imaging techniques.

This study develops a zebrafish model to longitudinally image meningeal cerebrovascular injury and immune responses, revealing vascular regrowth and immune cell interactions.

This paper introduces a new clearing reagent, LUCID, enabling high-resolution 3D imaging of whole zebrafish, including dense tissues like bone and cartilage, without significant distortion or signal loss.

The paper introduces an EpiTag zebrafish transgenic reporter to visualize epigenetic silencing/activation and identifies tissue-specific epigenetic regulatory genes through mutagenesis screening.

The paper uses a novel transgenic reporter to study epigenetic reprogramming during zebrafish fin regeneration, identifying early chromatin remodeling events and key factors required for regeneration.

This paper characterizes the zebrafish meninges using single-cell transcriptomics, identifying a novel cell type essential for brain development.

The paper identifies a new external immune organ in zebrafish, the axillary lymphoid organ, suitable for live imaging of immune cell dynamics.

This paper develops a zebrafish xenograft model for diffuse midline glioma by transplanting human DMG cells into zebrafish embryos to enable high-throughput drug screening.

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

The paper introduces a zebrafish transgenic line to profile endothelial cell translatomes in vivo, revealing novel genes and expression signatures across adult organs.

This paper introduces a method for long-term imaging of live adult zebrafish using a 3D printed chamber, enabling nearly day-long observation of neutrophil recruitment in transgenic fish.

The paper documents the stepwise development of the zebrafish pectoral fin vascular network using high-resolution imaging, revealing a stereotyped process involving initial vascular loops and three distinct plexuses.

This paper demonstrates the use of CRISPR-Cas9 dgRNPs to generate pigment-free, immobile zebrafish embryos and larvae across genetic backgrounds, enhancing live imaging capabilities.

This study investigates the in vivo roles of RHOA in vascular development and integrity using zebrafish models, finding that both gain- and loss-of-function lead to vascular dysfunction.

The paper identifies a meningeal lymphatic network in zebrafish, comparable to mammals, and demonstrates its function in draining brain interstitial fluid and immune cell trafficking.

This study identifies a mutation in the cbsa gene as a contributor to eye loss in cavefish by disrupting optic vasculature and causing hypoxia.

This study examines evolutionary changes in left-right visceral asymmetry in Astyanax cavefish, identifying maternal genetic effects and regulatory changes in the lft2 gene.

This study identifies miR-204 as a key regulator of lymphangiogenesis, showing its role in lymphatic vessel formation and its interaction with NFATC1.