Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment
Margaret E. Maes, Gabriele M Wögenstein, Gloria Colombo, Raquel Casado-Polanco, Sandra Siegert
The paper optimizes AAV2/6 for microglial targeting in the retina, showing enhanced transduction during photoreceptor degeneration through capsid modification and Cre-dependent cassette validation.
Molecular Therapy — Methods & Clinical Development · Sep 14, 2021Peer-reviewedNeuroscience