Sandra Siegert

This study examines nanoscale changes in synaptic proteins in human temporal lobe epilepsy, finding increased AMPA receptor density and altered calcium channel organization in specific synapse types.

The paper identifies a female-selective corticosterone-mediated microglia-neuron interaction during ketamine anesthesia recovery that drives neuronal plasticity.

The paper introduces a method to analyze organelle spatial organization in branched cells, finding distinct spatial programs in microglia under different conditions.

This study shows that growth-repulsion feedback in branched cells leads to hyperuniform tissue patterning and efficient tiling during development.

The paper shows that microglia in retinal organoids influence inflammation and enhance ibuprofen's protective effects against immune challenges during embryonic development.

The paper quantifies retinal ganglion cell (RGC) numbers in the contralateral eye after optic nerve crush and finds no RGC loss, contradicting previous reports.

The paper introduces MorphOMICs, a topological data analysis method to identify sex- and region-dependent microglial morphological phenotypes across development and neurodegeneration.

This study examines mitochondrial network adaptations in microglia under injury and UCP2 knockout, revealing sex-specific differences in stress response.

The paper introduces CATS, a method to map brain tissue architecture across scales, demonstrating its application to hippocampal mossy fiber circuitry.

The paper introduces DREADD-based GPCR chimeras to study cell type-specific signaling and microglia responses without endogenous ligands.

The paper identifies microglia-like cells forming in retinal organoids and characterizes their protein composition and localization.

The paper optimizes AAV2/6 for microglial targeting in the retina, showing enhanced transduction during photoreceptor degeneration through capsid modification and Cre-dependent cassette validation.