Gloria Colombo

Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye.

The paper quantifies retinal ganglion cell (RGC) numbers in the contralateral eye after optic nerve crush and finds no RGC loss, contradicting previous reports.

Microglial MorphOMICs unravel region- and sex-dependent morphological phenotypes from postnatal development to degeneration

The paper introduces MorphOMICs, a topological data analysis method to identify sex- and region-dependent microglial morphological phenotypes across development and neurodegeneration.

Mitochondrial networks of microglia adapt in a sex-specific manner upon injury-induced stress and UCP2 knockout

This study examines mitochondrial network adaptations in microglia under injury and UCP2 knockout, revealing sex-specific differences in stress response.

Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses

The paper introduces DREADD-based GPCR chimeras to study cell type-specific signaling and microglia responses without endogenous ligands.

Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment

The paper optimizes AAV2/6 for microglial targeting in the retina, showing enhanced transduction during photoreceptor degeneration through capsid modification and Cre-dependent cassette validation.