Gabriele M Wögenstein

The paper examines energy metabolism in retinal neurons, showing photoreceptors use both aerobic glycolysis and OXPHOS while inner retinal neurons rely on OXPHOS, and identifies metabolic changes in a retinitis pigmentosa mutation.

This paper develops a dual-acting RNAi therapy targeting Hif1a and Hif2a to protect retinal cells in AMD models, showing superior efficacy compared to single-target therapies.

The paper optimizes AAV2/6 for microglial targeting in the retina, showing enhanced transduction during photoreceptor degeneration through capsid modification and Cre-dependent cassette validation.