Cell BiologyFrontiers in Molecular BiosciencesPeer-reviewed
Protease-Activated Receptor 1 as an Endogenous Model of Peptidergic Gαq-Gα12-Biased G Protein Signaling
Braden S. Fallon, Robert A. Campbell, Justin G. English
This paper investigates how different proteases shape G protein signaling through PAR1, showing thrombin activates Gq and G12 while aPC only activates G12, with distinct transcriptional and physiological outcomes.
DOI 10.3389/fmolb.2026.1822420