Autophosphorylation of the oncogenic protein TEL-ABL confers resistance to the allosteric ABL inhibitor asciminib
Serena Muratcioğlu, Christopher A. Eide, Chien‐Lun Hung, Kent Gorday, Emily Sumpena, Wenqi Zuo, Jay T. Groves, Brian J. Druker, John Kuriyan
The paper shows that phosphorylation of TEL-ABL makes it resistant to asciminib, but dephosphorylation restores sensitivity.
Science Signaling · Jul 15, 2025Peer-reviewedBiochemistry