Author

Francesca Romana Iacobini

University of FribourgORCID 0000-0001-8339-6909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Markus M. GeisleriD· 2 shared Tamás HegedűsiD· 2 shared Alexandra SiffertiD· 1 shared Aurélien BaillyiD· 1 shared Hong Wei· 1 shared Jennifer L. SapiaiD· 1 shared Jian Ling XiaiD· 1 shared Joanna BanasiakiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Markus M. GeislerORCID

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2 papers

Recent·Most cited

The FKBP42, TWISTED DWARF1, prioritizes auxin over brassinosteroid transport by peptidyl-prolyl cis-trans isomerization of ABCB1

Tashi Tsering, Francesca Romana Iacobini, Jennifer L. Sapia, Martin Di Donato, Aurélien Bailly, Peter Hunyadi, Xiaoyu Xia, Hong Wei, Tamás Hegedűs, Markus M. Geisler

The paper shows TWD1 enhances IAA transport by isomerizing the E1007-P1008 bond in ABCB1, while not affecting BL transport, revealing a mechanism that prioritizes auxin over brassinosteroid transport.

bioRxiv · Jul 27, 2026 · PreprintBiochemistry

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

Jian Ling Xia, Alexandra Siffert, Odalys Torres, Francesca Romana Iacobini, Joanna Banasiak, Konrad Pakuła, Jörg Ziegler, Sabine Rosahl, Noel Ferro, Michał Jasiński, Tamás Hegedűs, Markus M. Geisler

The paper shows that mutation of L704 in ABCG36 affects substrate specificity by altering transport of IBA and CLX, with molecular dynamics supporting a quality control role.

Nature Communications · May 5, 2025Peer-reviewedBiochemistry