A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity
Jian Ling Xia, Alexandra Siffert, Odalys Torres, Francesca Romana Iacobini, Joanna Banasiak, Konrad Pakuła, Jörg Ziegler, Sabine Rosahl, Noel Ferro, Michał Jasiński, Tamás Hegedűs, Markus M. Geisler
The paper shows that mutation of L704 in ABCG36 affects substrate specificity by altering transport of IBA and CLX, with molecular dynamics supporting a quality control role.
Nature Communications · May 5, 2025Peer-reviewedBiochemistry