Author

Colin K.W. Lim

University of Illinois Urbana-ChampaignORCID 0000-0001-8370-4609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Daniela Del Bosque SilleriD· 2 shared Thomas GajiD· 2 shared Abhishek Bhattacharjee· 1 shared Alisha Y. XiongiD· 1 shared Anagha S. Dangi· 1 shared Ananthan NambiariD· 1 shared Angelo MiskalisiD· 1 shared Anna X.A. Wang· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

Daniela Del Bosque SillerORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedJul 29, 2026

In vivo CRISPR base editing for treatment of Huntington's disease

Shraddha Shirguppe, Michael Gapinske, Devyani Swami…·Pablo Pérez‐Piñera

This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.

8 citationstop 3%

mouseexperimental assay

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BioengineeringMolecular TherapyPeer-reviewedApr 24, 2026

Treatment of Huntington's disease with a pan-HTT-targeting CRISPR nuclease

Katherine Tan, Daniela Del Bosque Siller, Alisha Y. Xiong…·Thomas Gaj

This study develops a CRISPR-Cas9 system targeting all HTT alleles in HD mouse models, reducing mutant HTT and improving disease symptoms.

5 citationstop 1%

mousegenetic perturbation / CRISPR

𝕏 PostBluesky