Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response
Stefanie Höfer, Larissa Frasch, Sarah Brajkovic, Kerstin Putzker, Joe Lewis, Hendrik Schürmann, Valentina Leone, Amirhossein Sakhteman, Matthew The, Florian P Bayer, Julian Müller, Firas Hamood, Jens Thomas Siveke, Maximilian Reichert, Bernhard Küster
This study identifies ATR inhibitors as synergistic with gemcitabine in killing PDAC cells by blocking the DNA damage response pathway.
Molecular Systems Biology · Jan 21, 2025Peer-reviewedCancer Biology