Joe Lewis

Electrostatic interactions compensate energetic frustration in the coupled folding and binding of intrinsically disordered proteins

The paper investigates the energy landscape of coupled folding and binding in intrinsically disordered proteins, finding that electrostatic interactions compensate for energetic frustration.

Gemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response

This study identifies ATR inhibitors as synergistic with gemcitabine in killing PDAC cells by blocking the DNA damage response pathway.

Inferring tumor-specific cancer dependencies through integrating ex-vivo drug response assays and drug-protein profiling

The paper develops a method to infer tumor-specific molecular dependencies by integrating drug response assays with protein-drug affinity profiles, identifying known and novel dependencies in cancer types.

The scaffold protein IQGAP1 links heat-induced stress signals to alternative splicing regulation in gastric cancer cells

This study identifies IQGAP1 as a scaffold protein linking heat-induced stress signals to alternative splicing regulation in gastric cancer cells, showing its role in controlling hnRNPM sumoylation and AS of a cell cycle-related RNA regulon.