Alberto De Iaco

The paper shows that deleting large KRAB-ZFP gene clusters in mice leads to retrotransposon activation, indicating most KRAB-ZFPs are non-essential for transposon suppression.

This study shows that DUX regulates transcription during early embryonic cell divisions in mice but is not strictly essential for embryogenesis.

This study identifies DPPA2 and DPPA4 as essential for activating Dux and LINE-1 transcription, which is critical for zygotic genome activation in mouse embryos.