Molecular BiologybioRxivPreprint
The activation of ATR during unperturbed DNA replication is restricted by VCP/p97 through the extraction of DNA polymerase α/Primase from chromatin
Sara Rodríguez‐Acebes, Rodrigo Martín-Rufo, Alicia Gómez-Moya…·Emilio Lecona
This study shows that VCP/p97 restricts ATR activation during unperturbed S phase by removing DNA polymerase α/Primase from chromatin, preventing excessive replication fork activation and genomic instability.
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