Juan Méndez

This study shows that VCP/p97 restricts ATR activation during unperturbed S phase by removing DNA polymerase α/Primase from chromatin, preventing excessive replication fork activation and genomic instability.

This study shows that PrimPol creates single-stranded gaps at bulky DNA adducts, which recruit RAD51 for homologous recombination, facilitating DNA repair in mammalian cells.

This study identifies PrimPol as a key player in ICL traverse, showing its primase activity is required for DNA damage tolerance and that its absence increases sensitivity to ICL-inducing drugs.

The paper investigates how 3D chromatin structure and chromatin environment influence DNA replication origin activation efficiency in mouse embryonic stem cells under stress and control conditions.