Author

Luis Ignacio Toledo

University of CopenhagenORCID 0000-0001-9509-9944Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alejandra Perona· 1 shared Alejandro Fernández-LlorenteiD· 1 shared Alicia Gómez-MoyaiD· 1 shared Christian Friberg NielseniD· 1 shared Elena Martín‐DonceliD· 1 shared Emilio LeconaiD· 1 shared Guillermo de la Vega-BarrancoiD· 1 shared Ian David HicksoniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alejandra Perona

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2 papers

Recent·Most cited

Cell BiologyMolecular & Cellular ProteomicsPeer-reviewedJan 27, 2025

Quantitative chromatin protein dynamics during replication origin firing in human cells

Sampath Amitash Gadi, Ivo Alexander Hendriks, Christian Friberg Nielsen…·Luis Ignacio Toledo

The paper uses proteomics to analyze protein dynamics during replication origin firing in human cells, identifying NCAPH2 as a novel factor required for efficient origin firing.

1 citation

humanproteomics

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Molecular BiologybioRxivPreprintJul 25, 2022

The activation of ATR during unperturbed DNA replication is restricted by VCP/p97 through the extraction of DNA polymerase α/Primase from chromatin

Sara Rodríguez‐Acebes, Rodrigo Martín-Rufo, Alicia Gómez-Moya…·Emilio Lecona

This study shows that VCP/p97 restricts ATR activation during unperturbed S phase by removing DNA polymerase α/Primase from chromatin, preventing excessive replication fork activation and genomic instability.

1 citation

experimental assay

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