Qihui Shi

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

This study uses spatial multi-omics to show cSCLC has a monoclonal origin, lineage plasticity, and distinct microenvironment niches, leading to a new diagnostic assay.

DTCFinder detects and characterizes disseminated and circulating tumor cells in liquid biopsies using single-cell RNA sequencing and machine learning without relying on labels or markers.