Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer
Yapeng Su, Chunmei Liu, Xiang Lu, Hui-Yu Chuang, Guideng Li, Shiqun Shao, Yan Kong, Jihoon William Lee, Rachel H. Ng, Stephanie Wong, Lídia Robert, Charles Warden, Victoria Liu, Jie Chen, Zhuo Wang, , Wei Wei
This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.
Nature Communications · Apr 15, 2026Peer-reviewedCancer Biology