Author

Charles Warden

City Of Hope National Medical CenterORCID 0000-0002-1827-4486Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Xiwei WuiD· 3 shared Alphonsus H. C. NgiD· 1 shared Anne Barasa· 1 shared Antoni RibasiD· 1 shared Chunmei Liu· 1 shared Daniel CheniD· 1 shared David BaltimoreiD· 1 shared David H Mulama· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Xiwei WuORCID

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Author profile →

4 papers

Recent·Most cited

Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer

Yapeng Su, Chunmei Liu, Xiang Lu, Hui-Yu Chuang, Guideng Li, Shiqun Shao, Yan Kong, Jihoon William Lee, Rachel H. Ng, Stephanie Wong, Lídia Robert, Charles Warden, Victoria Liu, Jie Chen, Zhuo Wang, , Wei Wei

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

Nature Communications · Apr 15, 2026Peer-reviewedCancer Biology

Critical Differential Expression Assessment for Individual Bulk RNA-Seq Projects

Charles Warden, Xiwei Wu

The paper evaluates differential expression methods in bulk RNA-Seq by comparing edgeR-robust and DESeq2 in cell line and cancer data, highlighting the need for method testing in genomics projects.

bioRxiv · Feb 10, 2024 · PreprintGenomics

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegeneration

Teresa Ubina, Martha Magallanes, Saumya Srivastava, Charles Warden, Jiing‐Kuan Yee, Paul M. Salvaterra

This paper creates a human embryonic stem cell model of Aβ-dependent neurodegeneration, showing Aβ42 causes more severe phenotypes than Aβ40.

Frontiers in Neuroscience · Sep 20, 2019Peer-reviewedNeuroscience

Identification of a Novel Neutralizing and Two Non-Neutralizing Epitopes on Epstein-Barr Virus gp350 Protein

Lorraine Z Mutsvunguma, Anne Barasa, Charles Warden, Joslyn Foley, Murali Muniraju, David H Mulama, Peng Ye, Hanjun Qin, Jinhui Wang, Xiwei Wu, Waithaka Mwangi, Javier Gordon Ogembo

This study identifies nine epitopes on EBV gp350, including two novel neutralizing epitopes, through monoclonal antibody analysis and epitope mapping.

bioRxiv · Apr 17, 2018 · PreprintImmunology